Endocrine Abstracts

Teriparatide (TPTD) reduces the vertebral and nonvertebral fracture risk. TPTD increases bone formation and improves the cancellous bone microstructure which is an important determinant of the mechanical integrity of vertebrae. The aim of our study was to evaluate first time the effect of TPTD on cortical microstructure and dynamic histomorphometric indices in patients with osteoporosis with or without prior therapy with ALN. Sixty-six postmenopausal women with osteoporosis, m...

Introduction: Selective oestrogen receptor modulators function as oestrogen receptor antagonist in the breast and gonads, while they have agonistic effects on the bone and the cardiovascular system. It is also known that endogenously produced carbon monoxide by the heme-oxigenase (HO) enzyme exerts beneficial actions in cardiovascular protection.Design: Intact females, ovariectomized (OVX), raloxifene or oestrogen treated OVX Wistar rats were used. We st...